HAMP Domain Conformers That Propagate Opposite Signals in Bacterial Chemoreceptors
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چکیده
منابع مشابه
HAMP Domain Conformers That Propagate Opposite Signals in Bacterial Chemoreceptors
HAMP domains are signal relay modules in >26,000 receptors of bacteria, eukaryotes, and archaea that mediate processes involved in chemotaxis, pathogenesis, and biofilm formation. We identify two HAMP conformations distinguished by a four- to two-helix packing transition at the C-termini that send opposing signals in bacterial chemoreceptors. Crystal structures of signal-locked mutants establis...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2013
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1001479